Creatine kinase - Wikipedia
Simply stated at avesisland.info · Creatine+Kinase at the US National Library of Medicine Medical Subject Headings (MeSH); CPK. creatine is transported to skeletal muscle and stored in the form of creatine Almost no tubular reabsorption occurs, so the final creatinine levels in the blood and muscle concentrations of creatine and creatine phosphate remain raised for. Creatine phosphokinase, CK, CPK Levels of CK can rise after a heart attack, skeletal muscle injury, strenuous exercise, or drinking too much alcohol, and from .
CK is made up of three enzyme forms. CK-MB is the substance that rises if your heart muscle is damaged. CK-MM rises with other muscle damage. CK-BB is found mostly in the brain.
Why do I need this test? You may need this test if you have chest pain or weakness and your healthcare provider needs to find out if you've had a heart attack.
Your healthcare provider may also order this test if you have had a stroke or sports injury. But because levels of this protein may not peak for up to 2 days after certain injuries, you may need this test several times to see if your heart or other muscles have been damaged. Statin medicines are used to treat high cholesterol. They sometimes cause serious muscle injury.
Creatine Kinase (Blood) - Health Encyclopedia - University of Rochester Medical Center
In very rare cases they can even lead to a rapid, life-threatening muscle breakdown. What other tests might I have along with this test? Your healthcare provider may order other tests to find out if you have had a heart attack or muscle injury.
This is because cardiac troponin is more sensitive and more specific. Or the healthcare provider may order tests to see how you are recovering.
What do my test results mean?
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. The normal range for general CK varies by age and gender.
Greater muscle cell disturbance delays the appearance of a CK serum peak compared to less disruption. This may be linked to the time course of inflammation; however, evidence in the literature supporting this theory remains unclear. Conclusion The molecular mechanisms that result in CK release from muscle after mild exercise are unclear. More clarification could provide important information for athletes concerned about muscle hypertrophy, performance, and the importance of rest periods between periods of exercise.
Future studies should include an exploration of ethnic variations in CK response to exercise. In the absence of any mechanical muscle damage, it remains a question as to whether raised CK after exercise does represent a degree of actual muscle damage or some form of disruption in energy control processes or some other molecular reaction mechanism.
Since muscle tissue cannot ignore brain centred nerve stimulations causing increase in both the number of motor units recruited and the frequency of motor unit stimulation, as well as creation of longer tetanic contractions, it would seem logical that muscle would have some mechanism of moderation to delay the final sanction of fatigue for as long as possible.
Although PCr resynthesis is greatly diminished during high-intensity exercise, AMPK may still be required to maintain the ratio.
Difference between Creatine and Creatinine - Forum on Nutrition and Exercise - avesisland.info
It is speculated here that the control involves expulsion of CK from the cytosol see Figure 3. If this is the case, then increased serum CK levels arising from normal physical exercise may be a consequence of normal metabolic activity rather than representative of physical damage to muscle.
Such a system would not act in isolation but as part of a sophisticated process involving other regulatory functions in the muscle, and only when the full integrated system is understood will it be possible to explain the many anomalies associated with muscle action. Unfortunately, it has not been possible from the available literature to extract more definitive evidence for this suggestion.