Relationship between asthma severity and obesity

relationship between asthma severity and obesity

Download Citation on ResearchGate | Relationship Between Asthma Severity and Obesity | The prevalence of both obesity and asthma has risen in recent years. Thus we decided to investigate the relation between obesity and asthma severity. We undertook a cross-sectional study in outpatient asthma. To date, 2 studies have examined the relation of obesity to asthma severity or asthma control, 14 The first is a post hoc analysis of subjects with.

The odds ratio of the correlation between obesity and asthma severity was 1.

relationship between asthma severity and obesity

In the sample evaluated in this study no correlation between obesity and asthma severity was found for either gender. Asthma; Body mass index, Sex distribution; Obesity. Introduction Asthma is a chronic inflammatory disease characterized by lower airway hyperresponsiveness and by variable airflow limitation that can resolve spontaneously or through treatment.

This increases the influence on airway muscle contractility. Various studies have shown that the association between elevated BMI and asthma incidence is significantly stronger in women than in men.

Therefore, the aim of this study was to determine whether there is a correlation between BMI and the severity of asthma in individuals evaluated at a university hospital in Brazil. Patients and methods A retrospective study was conducted through the analysis of the reports of patients from the Asthma outpatient clinic of the Paulista State University School of Medicine at Botucatu. A total of asthma patients were studied. All were over the age of 20, and none presented any additional respiratory diseases.

Asthma severity was classified according to the criteria of the Brazilian Consensus on Asthma Management 1 as intermittent, mild persistent, moderate persistent or severe persistent. For the classification, we used the degree of severity established by the physician in charge of the patient and confirmed through the analysis of data regarding clinical history, physical examination, spirometry results and medication prescribed.

Association of Obesity with Asthma Severity, Control and Quality of Life

Gender, age, height, smoking habit, body weight, bronchodilator spirometry and prescribed medication were recorded. Statistics The study of the association between asthma severity and obesity was conducted using the Goodman test 20,21 for contrasts between and within multinomial proportions.

Logistic regression analysis was used for analyzing the associations among obesity, asthma severity and gender. Results The general characteristics of the patients studied according to BMI value are presented in Table 1. A total of There were 47 asthma patients who made no use of any regular medication, and the remaining used short-acting or long-acting b2-agonists on a regular or intermittent basis. Table 2 presents the result of the logistic regression that was employed in order to determine whether the prevalence of obesity was related to asthma severity.

The OR of the correlation between obesity and asthma severity was 1. For each degree of increase in asthma severity, the OR for obesity increases 0.

Relationship between asthma severity and obesity.

Table 3 shows the result of the Goodman test, which evaluated the probability of obesity according to gender and asthma severity. We observed that, although there is a trend toward an increase in obesity as asthma severity increases, for both genders, the percentage difference was not statistically significant.

The logistic regression used in order to evaluate the association between obesity and asthma severity among women also revealed no statistically significant difference. Therefore, no correlation between obesity and asthma severity was established in the sample studied.

Discussion The results of the present study show no correlation between obesity and asthma severity. Although there was an increase in the OR for obesity associated with an increase in asthma severity, the difference. When the groups were divided according to gender, no significant difference was found between men and women.

relationship between asthma severity and obesity

In that study, the authors observed that the percentage of obese patients among asthma patients was The correlation remained significant after adjustment for other risk factors, such as age, history of atopy and smoking, and was stronger among women.

Populational studies 5,13 evaluated the correlation between BMI values and the diagnosis of asthma among men and women and showed the correlation of asthma with higher and lower BMI values, with no defined cut-off point.

Association of Obesity with Asthma Severity, Control and Quality of Life

Indices that determine the distribution of fat in the thoracic-abdominal region can be more appropriate than the BMI for evaluating the influence of obesity on the respiratory system.

Therefore, the authors suggest that asthma symptoms are associated with body weight, regardless of the distribution of fat in the body.

  • There was a problem providing the content you requested

Furthermore, they do not allow the establishment of cut-off points for the nutritional indicators potentially associated with higher prevalence of the disease. There are few data referring to the correlation between obesity and asthma severity, and further studies are needed.

The physiopathology involving the superimposition of obesity on asthma remains unknown. Various mechanisms are involved. Those staunchly defended by some authors include low tolerance for physical activity, changes in respiratory mechanics and predisposition to gastroesophageal reflux, all of which occur in obese patients.

Therefore, the authors conclude that obesity is a risk factor for respiratory symptoms attributable to changes in the respiratory mechanics of these individuals, with no real evidence of airway obstruction or bronchial hyperreactivity.

University El Manar, Tunisia Corresponding author. This article has been cited by other articles in PMC. Abstract Background The association between asthma and obesity is becoming increasingly established but the mechanism that might explain the observed differences in asthma severity, control and quality of life between obese and non-obese adult asthmatics is not clear. The purpose of this study was: Materials and Methods A cross-sectional study was conducted between and Two hundred adult asthmatic patients were included.

Data analysis consisted of univariate analysis with chi-square comparison test followed by a multivariate logistic regression.

Relationship between asthma severity and obesity.

Results Obesity worsens the severity of asthma. This finding was more strongly observed among women than men. Obesity and overweight are associated with a poorer control of asthma. Conclusion In summary, it appears that obesity is significantly associated with a greater asthma severity and a poorer asthma control and quality of life. Chronic systemic inflammation state may explain the relationship between obesity and asthma.

Their prevalence has widely increased over the past decade. Asthma currently affects over 3. The prevalence of obesity is Many studies have confirmed the positive association between body mass index BMI and asthma 3 — 5. Thus, obesity might be associated with greater prevalence of asthma.

New Study Finds An Obesity and Asthma Link

Some studies suggest that asthma, in obese subjects, may have a particular phenotype. Therefore, obesity could contribute to greater severity of asthma and its poorer control.