Cerebellar mutism syndrome (CMS) is an important medical The cerebellar mutism syndrome and its relation to cerebellar cognitive function. One of the most disabling late effects of posterior fossa tumour surgery is the cerebellar mutism syndrome (CMS) which has been reported in up. The aim is to prospectively assess early neurocognitive outcome of children The cerebellar mutism syndrome and its relation to cerebellar.
This study highlights the need for careful follow-up with neuropsychological evaluation and for obtaining critical support for patients and their families. In order to reduce these lasting treatment-related effects, modern treatment trials have aimed to reduce the dosage of cranial radiation therapy or, in the case of young children, to delay the need for radiation therapy with chemotherapy.
Surgery remains the first phase of treatment for almost all patients and concerns regarding surgery-related complications exist. In addition, the development of CMS makes it very difficult, if not impossible, to conduct valid neuropsychological assessment until symptoms subside.
Of the few studies that do exist, most have been retrospective in nature 172223 or have concentrated on monitoring speech and language. Unfortunately, the report of perceived cognitive deficits included only average-risk patients and information was derived from written notes on a follow-up form, providing an estimation of function by the attending physician, rather than a direct formal evaluation.
Judged impairment was categorized as none, mild, moderate, or severe with no reference to how these categorizations were determined.
As a result, a clear understanding of the neuropsychological deficits faced specifically by those with CMS following surgery remains elusive.
The aims of the current study are i to prospectively assess the neurocognitive performance of those children who developed CMS following surgical resection of a posterior fossa embryonal tumor utilizing protocol-driven formal testing methods, and ii to compare the performance of those with CMS with that of disease, treatment, and demographically matched controls. Methods Patients and Procedures Study participants were recruited from an ongoing multisite IRB-approved clinical trial for patients newly diagnosed with an embryonal tumor.
Written informed consent was obtained for participation. At the time of the study, patients were enrolled on the protocol.
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